Recovering Actives in Multi-Antitarget and Target Design of Analogs of the Myosin II Inhibitor Blebbistatin
In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus test the limits of available technology, be that in screening large databases of compounds vs. a large number of targets, or in using in sili...
Main Authors: | Bart I. Roman, Rita C. Guedes, Christian V. Stevens, Alfonso T. García-Sosa |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-05-01
|
Series: | Frontiers in Chemistry |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2018.00179/full |
Similar Items
-
Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke
by: Wiebke Ewert, et al.
Published: (2020-10-01) -
K<sub>V</sub>11.1, Na<sub>V</sub>1.5, and Ca<sub>V</sub>1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
by: Magdalena Kowalska, et al.
Published: (2020-10-01) -
Mechanism and application of oxygen-independent photocleavage of blebbistatin as a blue or near-infrared light-gated hydroxyl radical photocage
by: Li, Ming-De, et al.
Published: (2020) -
The effective use of blebbistatin to study the action potential of cardiac pacemaker cells of zebrafish (Danio rerio) during incremental warming
by: L. Marchant James, et al.
Published: (2022-01-01) -
Blebbistatin Inhibits Neomycin-Induced Apoptosis in Hair Cell-Like HEI-OC-1 Cells and in Cochlear Hair Cells
by: Song Gao, et al.
Published: (2020-02-01)