Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency

Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency

Abstract Objectives Premature ovarian insufficiency (POI) refers to the decline and cessation of ovarian functions in women under 40 years of age. Melatonin (MT) acts as a protective for the ovary. This study elucidated the role of MT in autophagy of granulosa cells (GCs) in POI via modulating the p...

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Bibliographic Details
Main Authors: Di Wu, Wenjie Zhao, Chengjuan Xu, Xin Zhou, Xia Leng, Yanmin Li
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Women's Health
Subjects:
Premature ovarian insufficiency
Granulosa cells
Melatonin
miR-15a-5p
Stat3
PI3K-Akt-mTOR pathway
Online Access:https://doi.org/10.1186/s12905-022-02056-7

Internet

https://doi.org/10.1186/s12905-022-02056-7

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