Enhanced long term microcircuit plasticity in the valproic acid animal model of autism

Enhanced long term microcircuit plasticity in the valproic acid animal model of autism

A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperconnectivity of glutamatergic synapses and hyp...

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Bibliographic Details
Main Authors: Guilherme T Silva, Jean-Vincent Le Bé, Imad Riachi, Tania Rinaldi, Kamila Markram, Henry Markram
Format: Article
Language:English
Published: Frontiers Media S.A. 2009-06-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Neocortex
Valproic Acid
synaptic plasticity
ASD autism spectrum disorders
layer 5 pyramidal cells
long-term microcircuit plasticity
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.19.001.2009/full

Internet

http://journal.frontiersin.org/Journal/10.3389/neuro.19.001.2009/full

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