Method Development and Validation for the Simultaneous Quantitation of Pentoxifylline, Its Pharmacologically Active Metabolites, and Donepezil Using LC-MS/MS in Rat Plasma: Its Application to a Pharmacokinetic Study

Method Development and Validation for the Simultaneous Quantitation of Pentoxifylline, Its Pharmacologically Active Metabolites, and Donepezil Using LC-MS/MS in Rat Plasma: Its Application to a Pharmacokinetic Study

This study developed a simple, rapid, reproducible, and analytical method using liquid chromatography and electrospray ionization (ESI) with tandem mass spectrometry (LC-MS/MS) to simultaneously quantify pentoxifylline (PTX), its pharmacological active metabolites, lisofylline (PTX-M1) and 1-(3-carb...

Full description

Bibliographic Details
Main Authors: Sanghee Choi, Wang-Seob Shim, Jiyoung Yoon, Doowon Choi, Eunseo Song, Yeo Jin Choi, Soo-Heui Paik, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Separations
Subjects:
pentoxifylline
metabolites
donepezil
LC-MS/MS
plasma
validation
Online Access:https://www.mdpi.com/2297-8739/10/5/276

Internet

https://www.mdpi.com/2297-8739/10/5/276

Similar Items