SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

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Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD+-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the...

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Bibliographic Details
Main Authors: Jiyung Shin, Ming He, Yufei Liu, Silvana Paredes, Lidia Villanova, Katharine Brown, Xiaolei Qiu, Noushin Nabavi, Mary Mohrin, Kathleen Wojnoonski, Patrick Li, Hwei-Ling Cheng, Andrew J. Murphy, David M. Valenzuela, Hanzhi Luo, Pankaj Kapahi, Ronald Krauss, Raul Mostoslavsky, George D. Yancopoulos, Frederick W. Alt, Katrin F. Chua, Danica Chen
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005767

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http://www.sciencedirect.com/science/article/pii/S2211124713005767

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