RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells

RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that are required for anti-leukemic effects in murine KMT2A-MLLT3 leukemia cells, we unexpectedly identified RXRA DT448/9PP as a...

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Bibliographic Details
Main Authors: Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch
Format: Article
Language:English
Published: Ferrata Storti Foundation 2021-06-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/10300

Internet

https://haematologica.org/article/view/10300

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