c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for advanced cases of the disease. However, a variety of other transcription factors and signaling networks have been shown to b...

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Bibliographic Details
Main Authors: Stefan J. Barfeld, Alfonso Urbanucci, Harri M. Itkonen, Ladan Fazli, Jessica L. Hicks, Bernd Thiede, Paul S. Rennie, Srinivasan Yegnasubramanian, Angelo M. DeMarzo, Ian G. Mills
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:EBioMedicine
Subjects:
Prostate cancer
Glycine N-Methyltransferase (GNMT)
Chromatin immunoprecipitation exonuclease (ChIP-exo)
Androgen receptor
c-Myc
DNA damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301494

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http://www.sciencedirect.com/science/article/pii/S2352396417301494

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