Quantifying missing heritability at known GWAS loci.

Quantifying missing heritability at known GWAS loci.

Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs. However, it is currently unknown how much heritability is missing due to poor tagging or additional causal variants at known GWAS loci. Here, we...

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Detalles Bibliográficos
Main Authors: Alexander Gusev, Gaurav Bhatia, Noah Zaitlen, Bjarni J Vilhjalmsson, Dorothée Diogo, Eli A Stahl, Peter K Gregersen, Jane Worthington, Lars Klareskog, Soumya Raychaudhuri, Robert M Plenge, Bogdan Pasaniuc, Alkes L Price
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Acceso en liña:http://europepmc.org/articles/PMC3873246?pdf=render

Internet

http://europepmc.org/articles/PMC3873246?pdf=render

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