A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

Abstract While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that are essential for the resolution of DNA damage. By...

全面介绍

书目详细资料
Main Authors: Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual‐Reguant, Natalia Pardo‐Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci
格式: 文件
语言:English
出版: Springer Nature 2023-06-01
丛编:Molecular Systems Biology
主题:
aspartate metabolism
DNA damage response
electron transport chain
Peroxiredoxin 1
reactive oxygen species scavenging
在线阅读:https://doi.org/10.15252/msb.202211267

因特网

https://doi.org/10.15252/msb.202211267

相似书籍