A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability

Abstract While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that are essential for the resolution of DNA damage. By...

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Bibliographic Details
Main Authors: Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual‐Reguant, Natalia Pardo‐Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci
Format: Article
Language:English
Published: Springer Nature 2023-07-01
Series:Molecular Systems Biology
Subjects:
aspartate metabolism
DNA damage response
electron transport chain
Peroxiredoxin 1
reactive oxygen species scavenging
Online Access:https://doi.org/10.15252/msb.202211267

Internet

https://doi.org/10.15252/msb.202211267

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