Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections.

Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections.

BACKGROUND:About 90% of drugs fail in clinical development. The question is whether trials fail because of insufficient efficacy of the new treatment, or rather because of poor trial design that is unable to detect the true efficacy. The variance of the measured endpoints is a major, largely underes...

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Bibliographic Details
Main Authors: Carolin Vegvari, Emilie Cauët, Christoforos Hadjichrysanthou, Emma Lawrence, Gerrit-Jan Weverling, Frank de Wolf, Roy M Anderson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4917234?pdf=render

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http://europepmc.org/articles/PMC4917234?pdf=render

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