Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype

Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype

Background & Aims: Alpha-1 antitrypsin deficiency is caused by mutations in SERPINA1, most commonly homozygosity for the Pi∗Z variant, and can present as liver disease. While heterozygosity for Pi∗Z (Pi∗MZ) is linked to increased risk of cirrhosis, whether the Pi∗MZ genotype is associated wi...

Full description

Bibliographic Details
Main Authors: Vincent L. Chen, Daniel A. Burkholder, Isabel J. Moran, Jacob V. DiBattista, Matthew J. Miller, Yanhua Chen, Xiaomeng Du, Antonino Oliveri, Kelly C. Cushing, Anna S. Lok, Elizabeth K. Speliotes
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:JHEP Reports
Subjects:
Genetic epidemiology
single nucleotide polymorphism
survival analysis
competing risk
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922000556

Internet

http://www.sciencedirect.com/science/article/pii/S2589555922000556

Similar Items