cGAS-STING activation contributes to podocyte injury in diabetic kidney disease

cGAS-STING activation contributes to podocyte injury in diabetic kidney disease

Summary: Diabetic kidney disease (DKD) is the leading cause of end-stage renal diseases. DKD does not have efficacious treatment. The cGAS-STING pathway is activated in podocytes at the early stage of kidney dysfunction, which is associated with the activation of STING downstream effectors TBK1 and...

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Bibliographic Details
Main Authors: Nan Zang, Chen Cui, Xinghong Guo, Jia Song, Huiqing Hu, Mengmeng Yang, Mingyue Xu, Lingshu Wang, Xinguo Hou, Qin He, Zheng Sun, Chuan Wang, Li Chen
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
molecular biology
diabetology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222014171

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http://www.sciencedirect.com/science/article/pii/S2589004222014171

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