Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities

With the aim to identify novel inhibitors of parasitic nematode thymidylate synthase (TS), we screened in silico an in-house library of natural compounds, taking advantage of a model of nematode TS three-dimensional (3D) structure and choosing candidate compounds potentially capable of enzyme bindin...

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Bibliographic Details
Main Authors: Piotr Maj, Mattia Mori, Justyna Sobich, Joanna Markowicz, Łukasz Uram, Zbigniew Zieliński, Deborah Quaglio, Andrea Calcaterra, Ylenia Cau, Bruno Botta, Wojciech Rode
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
thymidylate synthase
inhibitor
nematocidal activity
cytotoxicity
xanthones
Online Access:https://www.mdpi.com/1420-3049/25/12/2894

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https://www.mdpi.com/1420-3049/25/12/2894

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