Toxicokinetics and Tissue Distribution of the Hepatotoxic Triterpenoid Saponin Pterocephin A in Rats Using the Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS) Method

Toxicokinetics and Tissue Distribution of the Hepatotoxic Triterpenoid Saponin Pterocephin A in Rats Using the Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS) Method

Pterocephin A is a natural triterpenoid saponin isolated from <i>Pterocephalus hookeri</i>, a traditional Tibetan medicine with slight toxicity, which can induce liver injury in rats. This study aimed to establish a sensitive and reliable UPLC-MS/MS method for exploring the toxicokinetic...

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Bibliographic Details
Main Authors: Yiran Xiong, Zhaoyue Dong, Hongxu Zhou, Jingxin Mao, Lingjiang Zeng, Yunbin Jiang, Fancheng Meng, Zhihua Liao, Min Chen
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Molecules
Subjects:
pterocephin A
toxicokinetics
tissue distribution
UPLC-MS/MS
<i>Pterocephalus hookeri</i>
Online Access:https://www.mdpi.com/1420-3049/29/21/5044

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https://www.mdpi.com/1420-3049/29/21/5044

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