Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin’s lymphoma

Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin’s lymphoma

Nodular lymphocyte-predominant Hodgkin’s lymphoma (NLPHL) shows constitutive NF-κB activity in the malignant lymphocyte-predominant (LP) cells. Constitutive NF-κB activity also plays a central pathogenetic role in classical Hodgkin’s lymphoma (cHL), where inactivating mutations in the NFKBIA and TNF...

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Bibliographic Details
Main Authors: Martin A. Schumacher, Roland Schmitz, Verena Brune, Enrico Tiacci, Claudia Döring, Martin-Leo Hansmann, Reiner Siebert, Ralf Küppers
Format: Article
Language:English
Published: Ferrata Storti Foundation 2010-01-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/5463

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https://haematologica.org/article/view/5463

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