Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation

Recent advances in image reconstruction techniques have enabled high resolution MRI studies of fetal brain development in human subjects. Rhesus macaques (Macaca mulatta) are valuable animal models for use in studies of fetal brain development due to the similarities between this species and humans...

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Main Authors: Zheng Liu, Xiaojie Wang, Natali Newman, Kathleen A. Grant, Colin Studholme, Christopher D. Kroenke
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:NeuroImage
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811919309012
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author Zheng Liu
Xiaojie Wang
Natali Newman
Kathleen A. Grant
Colin Studholme
Christopher D. Kroenke
author_facet Zheng Liu
Xiaojie Wang
Natali Newman
Kathleen A. Grant
Colin Studholme
Christopher D. Kroenke
author_sort Zheng Liu
collection DOAJ
description Recent advances in image reconstruction techniques have enabled high resolution MRI studies of fetal brain development in human subjects. Rhesus macaques (Macaca mulatta) are valuable animal models for use in studies of fetal brain development due to the similarities between this species and humans in brain development and anatomy. There is a need to develop fetal brain templates for the rhesus macaque to facilitate the characterization of the normal brain growth trajectory and departures from this trajectory in rhesus models of neurodevelopmental disorders. Here we have developed unbiased population-based anatomical T2-weighted, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) templates for fetal brain from MR images scanned at 3 time points over the second and third trimesters of the 168 day gestational term. Specifically, atlas images are constructed for brains at gestational ages of 85 days (G85, N = 18, 9 females), 110 days (G110, N = 10, 7 females) and 135 days (G135, N = 16, 7 females). We utilized this atlas to perform segmentation of fetal brain MR images and fetal brain volumetric and microstructure analysis. The T2-weighted template images facilitated characterization of the growth within six fetal brain regions. The template images of diffusion tensor indices provided information related to the maturation of white matter tracts. These growth trajectories are referenced to human studies of fetal brain development. Similarities in the temporal and regional patterns of brain growth over the corresponding periods of central nervous system development are identified between the two species. Atlas images are available online as a reference for registration, reconstruction, segmentation, and for longitudinal analysis of early fetal brain growth over this unique time window.
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spelling doaj.art-99a81de2c2c344d8a34ffe508db698182022-12-22T01:53:16ZengElsevierNeuroImage1095-95722020-02-01206116310Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestationZheng Liu0Xiaojie Wang1Natali Newman2Kathleen A. Grant3Colin Studholme4Christopher D. Kroenke5Division of Neuroscience, Oregon National Primate Research Center (ONPRC), United States; Advanced Imaging Research Center, Oregon Health and Science University (OHSU), United StatesDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), United States; Advanced Imaging Research Center, Oregon Health and Science University (OHSU), United StatesDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), United StatesDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), United States; Department of Behavioral Neuroscience, OHSU, United StatesBioengineering and Radiology, University of Washington, United StatesDivision of Neuroscience, Oregon National Primate Research Center (ONPRC), United States; Advanced Imaging Research Center, Oregon Health and Science University (OHSU), United States; Department of Behavioral Neuroscience, OHSU, United States; Corresponding author. Oregon Health & Science University, Mail Code L452 3181 SW Sam Jackson Park Road, Portland, 97239, OR, United States.Recent advances in image reconstruction techniques have enabled high resolution MRI studies of fetal brain development in human subjects. Rhesus macaques (Macaca mulatta) are valuable animal models for use in studies of fetal brain development due to the similarities between this species and humans in brain development and anatomy. There is a need to develop fetal brain templates for the rhesus macaque to facilitate the characterization of the normal brain growth trajectory and departures from this trajectory in rhesus models of neurodevelopmental disorders. Here we have developed unbiased population-based anatomical T2-weighted, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) templates for fetal brain from MR images scanned at 3 time points over the second and third trimesters of the 168 day gestational term. Specifically, atlas images are constructed for brains at gestational ages of 85 days (G85, N = 18, 9 females), 110 days (G110, N = 10, 7 females) and 135 days (G135, N = 16, 7 females). We utilized this atlas to perform segmentation of fetal brain MR images and fetal brain volumetric and microstructure analysis. The T2-weighted template images facilitated characterization of the growth within six fetal brain regions. The template images of diffusion tensor indices provided information related to the maturation of white matter tracts. These growth trajectories are referenced to human studies of fetal brain development. Similarities in the temporal and regional patterns of brain growth over the corresponding periods of central nervous system development are identified between the two species. Atlas images are available online as a reference for registration, reconstruction, segmentation, and for longitudinal analysis of early fetal brain growth over this unique time window.http://www.sciencedirect.com/science/article/pii/S1053811919309012
spellingShingle Zheng Liu
Xiaojie Wang
Natali Newman
Kathleen A. Grant
Colin Studholme
Christopher D. Kroenke
Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation
NeuroImage
title Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation
title_full Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation
title_fullStr Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation
title_full_unstemmed Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation
title_short Anatomical and diffusion MRI brain atlases of the fetal rhesus macaque brain at 85, 110 and 135 days gestation
title_sort anatomical and diffusion mri brain atlases of the fetal rhesus macaque brain at 85 110 and 135 days gestation
url http://www.sciencedirect.com/science/article/pii/S1053811919309012
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