Differential sensitivity to hypoxia enables shape‐based classification of sickle cell disease and trait blood samples at point of care

Differential sensitivity to hypoxia enables shape‐based classification of sickle cell disease and trait blood samples at point of care

Abstract Red blood cells (RBCs) become sickle‐shaped and stiff under hypoxia as a consequence of hemoglobin (Hb) polymerization in sickle cell anemia. Distinguishing between sickle cell disease and trait is crucial during the diagnosis of sickle cell disease. While genetic analysis or high‐performan...

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Bibliographic Details
Main Authors: Claudy D'Costa, Oshin Sharma, Riddha Manna, Minakshi Singh, Samrat Singh, Srushti Singh, Anish Mahto, Pratiksha Govil, Sampath Satti, Ninad Mehendale, Yazdi Italia, Debjani Paul
Format: Article
Language:English
Published: Wiley 2024-07-01
Series:Bioengineering & Translational Medicine
Subjects:
diagnostics
hemoglobin polymerization
RBC shape
shape‐based classifier
sickle cell anemia
smartphone microscopy
Online Access:https://doi.org/10.1002/btm2.10643

Internet

https://doi.org/10.1002/btm2.10643

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