E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin.

E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin.

Escape from the host immune system is essential for intracellular pathogens. The adenoviral protein E3-14.7K (14.7K) is known as a general inhibitor of tumor necrosis factor (TNF)-induced apoptosis. It efficiently blocks TNF-receptor 1 (TNFR1) internalization but the underlying molecular mechanism s...

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Bibliographic Details
Main Authors: Laura Klingseisen, Martin Ehrenschwender, Ulrike Heigl, Harald Wajant, Thomas Hehlgans, Stefan Schütze, Wulf Schneider-Brachert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3366936?pdf=render

Internet

http://europepmc.org/articles/PMC3366936?pdf=render

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