Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae

Variants of the Sir4 Coiled-Coil Domain Improve Binding to Sir3 for Heterochromatin Formation in Saccharomyces cerevisiae

Heterochromatin formation in the yeast Saccharomyces cerevisiae is characterized by the assembly of the Silent Information Regulator (SIR) complex, which consists of the histone deacetylase Sir2 and the structural components Sir3 and Sir4, and binds to unmodified nucleosomes to provide gene silencin...

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Bibliographic Details
Main Authors: Anke Samel, Adam Rudner, Ann E. Ehrenhofer-Murray
Format: Article
Language:English
Published: Oxford University Press 2017-04-01
Series:G3: Genes, Genomes, Genetics
Subjects:
gene silencing
repression
chromatin
Sir1
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.116.037739

Internet

http://g3journal.org/lookup/doi/10.1534/g3.116.037739

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