Dual Targeting of Y-Box Binding Protein-1 and Akt Inhibits Proliferation and Enhances the Chemosensitivity of Colorectal Cancer Cells

Dual Targeting of Y-Box Binding Protein-1 and Akt Inhibits Proliferation and Enhances the Chemosensitivity of Colorectal Cancer Cells

KRAS-mutated colorectal cancers (CRCs) are resistant to cetuximab treatment. The multifunctional Y-box binding protein 1 (YB-1) is overexpressed in CRC and is associated with chemoresistance. In this study, the effects of oncogenic mutated KRAS(G12V) and KRAS(G13D) on YB-1 phosphorylation were inves...

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Bibliographic Details
Main Authors: Eva Maier, Felix Attenberger, Aadhya Tiwari, Konstanze Lettau, Simone Rebholz, Birgit Fehrenbacher, Martin Schaller, Cihan Gani, Mahmoud Toulany
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
Y-box binding protein 1
colorectal cancer
5-fluorouracil
RSK
Akt
Online Access:https://www.mdpi.com/2072-6694/11/4/562

Internet

https://www.mdpi.com/2072-6694/11/4/562

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