Effect of S–Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel <i>N</i>-acylhydrazone Derivatives at the Adenosine A<sub>2A</sub> Receptor

Effect of S–Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel <i>N</i>-acylhydrazone Derivatives at the Adenosine A<sub>2A</sub> Receptor

In this work, we evaluated the conformational effect promoted by the isosteric exchange of sulfur by selenium in the heteroaromatic ring of new <i>N</i>-acylhydrazone (NAH) derivatives (<b>3</b>–<b>8</b>, <b>13</b>, <b>14</b>), analogues of...

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Bibliographic Details
Main Authors: Júlia Galvez Bulhões Pedreira, Rafaela Ribeiro Silva, François G. Noël, Eliezer J. Barreiro
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
<i>N</i>-acylhydrazone derivatives
A<sub>2A</sub> receptor
sulfur-selenium isosterism
conformational effect
chalcogen interaction
<i>N</i>-methylation effect
Online Access:https://www.mdpi.com/1420-3049/26/23/7364

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https://www.mdpi.com/1420-3049/26/23/7364

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