Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

The essential micronutrient Selenium (Se) is co-translationally incorporated as selenocysteine into proteins. Selenoproteins contain one or more selenocysteines and are vital for optimum immunity. Interestingly, many pathogenic bacteria utilize Se for various biological processes suggesting that Se...

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Bibliographic Details
Main Authors: Rachel L. Markley, Katherine H. Restori, Bhuvana Katkere, Sarah E. Sumner, McKayla J. Nicol, Anastasia Tyryshkina, Shaneice K. Nettleford, David R. Williamson, David E. Place, Kalyan K. Dewan, Ashley E. Shay, Bradley A. Carlson, Santhosh Girirajan, K. Sandeep Prabhu, Girish S. Kirimanjeswara
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
selenium
redox
intracellular bacteria
tularemia
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701341/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.701341/full

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