Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures.

Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures.

BACKGROUND: Recent advances toward an effective therapy for prion diseases employ RNA interference to suppress PrP(C) expression and subsequent prion neuropathology, exploiting the phenomenon that disease severity and progression correlate with host PrP(C) expression levels. However, delivery of len...

Full description

Bibliographic Details
Main Authors: Bruce Pulford, Natalia Reim, Aimee Bell, Jessica Veatch, Genevieve Forster, Heather Bender, Crystal Meyerett, Scott Hafeman, Brady Michel, Theodore Johnson, A Christy Wyckoff, Gino Miele, Christian Julius, Jan Kranich, Alan Schenkel, Steven Dow, Mark D Zabel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2885418?pdf=render

Internet

http://europepmc.org/articles/PMC2885418?pdf=render

Similar Items