Liposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures.
BACKGROUND: Recent advances toward an effective therapy for prion diseases employ RNA interference to suppress PrP(C) expression and subsequent prion neuropathology, exploiting the phenomenon that disease severity and progression correlate with host PrP(C) expression levels. However, delivery of len...
Main Authors: | Bruce Pulford, Natalia Reim, Aimee Bell, Jessica Veatch, Genevieve Forster, Heather Bender, Crystal Meyerett, Scott Hafeman, Brady Michel, Theodore Johnson, A Christy Wyckoff, Gino Miele, Christian Julius, Jan Kranich, Alan Schenkel, Steven Dow, Mark D Zabel |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2885418?pdf=render |
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