Canagliflozin ameliorates the development of NAFLD by preventing NLRP3-mediated pyroptosis through FGF21-ERK1/2 pathway

Recent studies have suggested that sodium-glucose co-transporter2 inhibitors go beyond their glycemic advantages to ameliorate the development of NAFLD. However, little research has been done on the underlying mechanisms. Here, we took deep insight into the effect of canagliflozin (CANA), one of the...

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Bibliographic Details
Main Authors: Shaohan Huang, Beibei Wu, Yingzi He, Ruojun Qiu, Tian Yang, Shuo Wang, Yongzhen Lei, Hong Li, Fenping Zheng
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2023-03-01
Series:Hepatology Communications
Online Access:http://journals.lww.com/10.1097/HC9.0000000000000045