Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling

Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling

Obesity-induced metabolic cardiomyopathy (MC), characterized by lipotoxicity and excessive oxidative stress, emerges as the leading cause of heart failure in the obese patients. Yet, its therapy remains very limited. Here, we demonstrated that isoginkgetin (IGK), a bioactive biflavonoid isolated fro...

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Bibliographic Details
Main Authors: Xiaoqian Wu, Jianrong Huang, Junyuan Tang, Yuling Sun, Guojun Zhao, Cuishi Yan, Zhenghong Liu, Wei Yi, Suowen Xu, Xiyong Yu
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
Obesity-induced cardiomyopathy
Mitochondrial dysfunction
Oxidative stress
Lipotoxicity
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002579

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722002579

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