Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin

Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin

Summary: Triphenylphosphonium (TPP+) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date, studies have focused on modifying either the linker or the cargo of TPP+-conjugated compounds. Here, we investigated the biological...

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Bibliographic Details
Main Authors: Mahmoud AbuEid, Robert F. Keyes, Donna McAllister, Francis Peterson, Ishaque Pulikkal Kadamberi, Daniel J. Sprague, Pradeep Chaluvally-Raghavan, Brian C. Smith, Michael B. Dwinell
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Pharmaceutical science
chemistry
biological sciences
biochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019423

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222019423

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