Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro

Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine...

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Bibliographic Details
Main Authors: Hua-Long Xiong, Jia-Li Cao, Chen-Guang Shen, Jian Ma, Xiao-Yang Qiao, Tian-Shu Shi, Sheng-Xiang Ge, Hui-Ming Ye, Jun Zhang, Quan Yuan, Tian-Ying Zhang, Ning-Shao Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
drug screening
SARS-CoV-2
pseudovirus assay
vesicular stomatitis virus
drug combination
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.609592/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.609592/full

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