Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro
To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.609592/full |
| _version_ | 1818452232153071616 |
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| author | Hua-Long Xiong Jia-Li Cao Jia-Li Cao Chen-Guang Shen Chen-Guang Shen Jian Ma Xiao-Yang Qiao Tian-Shu Shi Sheng-Xiang Ge Hui-Ming Ye Jun Zhang Quan Yuan Tian-Ying Zhang Ning-Shao Xia |
| author_facet | Hua-Long Xiong Jia-Li Cao Jia-Li Cao Chen-Guang Shen Chen-Guang Shen Jian Ma Xiao-Yang Qiao Tian-Shu Shi Sheng-Xiang Ge Hui-Ming Ye Jun Zhang Quan Yuan Tian-Ying Zhang Ning-Shao Xia |
| author_sort | Hua-Long Xiong |
| collection | DOAJ |
| description | To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM. |
| first_indexed | 2024-12-14T21:19:49Z |
| format | Article |
| id | doaj.art-99c6bb154816476bab9f54ea1e62d03a |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T21:19:49Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-99c6bb154816476bab9f54ea1e62d03a2022-12-21T22:46:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-02-011110.3389/fphar.2020.609592609592Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitroHua-Long Xiong0Jia-Li Cao1Jia-Li Cao2Chen-Guang Shen3Chen-Guang Shen4Jian Ma5Xiao-Yang Qiao6Tian-Shu Shi7Sheng-Xiang Ge8Hui-Ming Ye9Jun Zhang10Quan Yuan11Tian-Ying Zhang12Ning-Shao Xia13State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaDepartment of Clinical Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, ChinaShenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, ChinaSchool of Public Health, Southern Medical University, Guangzhou, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaDepartment of Clinical Laboratory, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, ChinaTo identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.https://www.frontiersin.org/articles/10.3389/fphar.2020.609592/fulldrug screeningSARS-CoV-2pseudovirus assayvesicular stomatitis virusdrug combination |
| spellingShingle | Hua-Long Xiong Jia-Li Cao Jia-Li Cao Chen-Guang Shen Chen-Guang Shen Jian Ma Xiao-Yang Qiao Tian-Shu Shi Sheng-Xiang Ge Hui-Ming Ye Jun Zhang Quan Yuan Tian-Ying Zhang Ning-Shao Xia Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro Frontiers in Pharmacology drug screening SARS-CoV-2 pseudovirus assay vesicular stomatitis virus drug combination |
| title | Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro |
| title_full | Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro |
| title_fullStr | Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro |
| title_full_unstemmed | Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro |
| title_short | Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro |
| title_sort | several fda approved drugs effectively inhibit sars cov 2 infection in vitro |
| topic | drug screening SARS-CoV-2 pseudovirus assay vesicular stomatitis virus drug combination |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.609592/full |
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