Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension

Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension

AimsWe hypothesized that the ATP-sensitive K+ channels (KATP) regulatory subunit (ABCC9) contributes to PAH pathogenesis. ABCC9 gene encodes for two regulatory subunits of KATP channels: the SUR2A and SUR2B proteins. In the KATP channel, the SUR2 subunits are associated with the K+ channel Kir6.1. W...

Full description

Bibliographic Details
Main Authors: Hélène Le Ribeuz, Bastien Masson, Mary Dutheil, Angèle Boët, Antoine Beauvais, Jessica Sabourin, Vincent Thomas De Montpreville, Véronique Capuano, Olaf Mercier, Marc Humbert, David Montani, Fabrice Antigny
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ATP
ABCC9
pulmonary arterial tone
migration
proliferation
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1066047/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.1066047/full

Similar Items