Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ<sub>42</sub> accumulation and Caspase-3 activation

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ<sub>42</sub> accumulation and Caspase-3 activation

<p>Abstract</p> <p>Background</p> <p>Although the mechanism of neuron loss in Alzheimer’s disease (AD) is enigmatic, it is associated with cerebral accumulation of Aβ<sub>42</sub>. The 5XFAD mouse model of amyloid deposition expresses five familial AD (FAD)...

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Bibliographic Details
Main Authors: Eimer William A, Vassar Robert
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Molecular Neurodegeneration
Subjects:
Intraneuronal Aβ<sub>42</sub>
5XFAD
Alzheimer’s disease
Amyloid-β
Caspase-3
Neuron loss
Apoptosis
Online Access:http://www.molecularneurodegeneration.com/content/8/1/2

Internet

http://www.molecularneurodegeneration.com/content/8/1/2

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