Domino Aza-Michael-S<sub>N</sub>Ar-Heteroaromatization Route to C5-Substituted 1-Alkyl-1<i>H</i>-Indole-3-Carboxylic Esters
A new synthesis of C5-substituted 1-alkyl-1<i>H</i>-indole-3-carboxylic esters is reported. A series of methyl 2-arylacrylate aza-Michael acceptors were prepared with aromatic substitution to activate them towards S<sub>N</sub>Ar reaction. Subsequent reaction with a series of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/20/6998 |