C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation

C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation

Dysregulated NLRP3 inflammasome activation drives a wide variety of diseases, while endogenous inhibition of this pathway is poorly characterised. The serum protein C4b-binding protein (C4BP) is a well-established inhibitor of complement with emerging functions as an endogenously expressed inhibitor...

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Bibliographic Details
Main Authors: Damien Bierschenk, Nikolina Papac-Milicevic, Ian P. Bresch, Valentina Kovacic, Serena Bettoni, Mateusz Dziedzic, Rick A. Wetsel, Susanne Eschenburg, Christoph J. Binder, Anna M. Blom, Ben C. King
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
inflammasome
C4BP
cytokine
pyroptosis
gout
MSU
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1149822/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1149822/full

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