Association of the Somatostatin Analog Octreotide With Magnetic Nanoparticles for Intraocular Delivery: A Possible Approach for the Treatment of Diabetic Retinopathy

Association of the Somatostatin Analog Octreotide With Magnetic Nanoparticles for Intraocular Delivery: A Possible Approach for the Treatment of Diabetic Retinopathy

The somatostatin analog octreotide (OCT) displays important neuroprotective and anti-angiogenic properties that could make it an interesting candidate to treat diabetic retinopathy (DR). Unfortunately, systemic drug administration is hindered by severe side effects, therefore topical administration...

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Bibliographic Details
Main Authors: Rosario Amato, Martina Giannaccini, Massimo Dal Monte, Maurizio Cammalleri, Alessandro Pini, Vittoria Raffa, Matteo Lulli, Giovanni Casini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
mammalian retina
pigment epithelium
endothelial cells
retinal explants
apoptosis
biocompatibility
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00144/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00144/full

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