An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment

An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment

Intratumoral hypoxia is a widely established element of the pancreatic tumor microenvironment (TME) promoting immune escape, tumor invasion, and progression, while contributing to treatment resistance and poor survival. Despite this critical role, hypoxia is underrepresented in molecular signatures...

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Bibliographic Details
Main Authors: Raefa Abou Khouzam, Shyama Prasad Rao, Goutham Hassan Venkatesh, Nagwa Ahmed Zeinelabdin, Stephanie Buart, Maxime Meylan, Manjunath Nimmakayalu, Stéphane Terry, Salem Chouaib
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
hypoxia
pancreatic cancer
prognostic
signature
tumor inflammation
microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.680435/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.680435/full

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