CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice

CSF-1R inhibitor PLX3397 attenuates peripheral and brain chronic GVHD and improves functional outcomes in mice

Abstract Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in peripheral organs as well as the brain and is a frequent cause of late morbidity and death after bone-marrow transpl...

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Bibliographic Details
Main Authors: Samreen N. Shaikh, Emily F. Willis, Max Dierich, Yi Xu, Samuel J. S. Stuart, Glenda C. Gobe, Abate A. Bashaw, Oliver Rawashdeh, Seung Jae Kim, Jana Vukovic
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Neuroinflammation
Subjects:
Bone-marrow transplant
Chronic GVHD
Macrophage depletion
Colony stimulating factor-1 receptor
Cognitive dysfunction
Online Access:https://doi.org/10.1186/s12974-023-02984-7

Internet

https://doi.org/10.1186/s12974-023-02984-7

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