The role of the SGK3/TOPK signaling pathway in the transition from acute kidney injury to chronic kidney disease

The role of the SGK3/TOPK signaling pathway in the transition from acute kidney injury to chronic kidney disease

Introduction: Profibrotic phenotype of renal tubular epithelial cells (TECs) featured with epithelial to mesenchymal transition (EMT) and profibrotic factors secretion, and aberrant accumulation of CD206+ M2 macrophages are the key points in the transition from acute kidney injury (AKI) to chronic k...

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Bibliographic Details
Main Authors: Huapan Shu, Yumei Wang, Hui Zhang, Qingqing Dong, Lulu Sun, Yuchi Tu, Qianqian Liao, Li Feng, Lijun Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
acute kidney injury
chronic kidney disease
macrophages
renal tubular epithelial cells
epithelial-to-mesenchymal transition
macrophage-to-myofibroblast transition
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1169054/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1169054/full

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