Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies

BackgroundMale testicular dysfunction is a considerable complication of anti-cancer therapies, including chemotherapy and radiotherapy, partly due to the increased oxidative stress caused by these treatments. Melatonin is an effective antioxidant agent that protects testicles against physical and to...

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Main Authors: Niloofar Dehdari Ebrahimi, Alireza Sadeghi, Sara Shojaei-Zarghani, Mohammad Amin Shahlaee, Erfan Taherifard, Zahra Rahimian, Zahra Eghlidos, Negar Azarpira, Ali Reza Safarpour
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Endocrinology
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Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1184745/full