Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.

Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.

Pleiotrophin (PTN) is a growth factor with both pro-angiogenic and limited pro-tumorigenic activity. We evaluated the potential for PTN to be used for safe angiogenic gene therapy using the full length gene and a truncated gene variant lacking the domain implicated in tumorigenesis. Mouse myoblasts...

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Bibliographic Details
Main Authors: Qizhi Fang, Pamela Y Mok, Anila E Thomas, Daniel J Haddad, Shereen A Saini, Brian T Clifford, Neel K Kapasi, Olivia M Danforth, Minako Usui, Weisheng Ye, Emmy Luu, Rikki Sharma, Maya J Bartel, Jeremy A Pathmanabhan, Andrew A S Ang, Richard E Sievers, Randall J Lee, Matthew L Springer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3632611?pdf=render

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http://europepmc.org/articles/PMC3632611?pdf=render

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