Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study
BackgroundAlthough studies suggest that concentrations of serum 25-hydroxyvitamin D (25(OH)D) are lower in individuals with Heart Failure (HF), the beneficial effects of vitamin D supplementation are controversial. Therefore, in this study, we aimed to determine whether there is a causal relationshi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.910949/full |
| _version_ | 1811248449608220672 |
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| author | Ning Gao Xuebiao Li Minjian Kong Ming Ni Dongdong Wei Xian Zhu Yifan Wang Ze Hong Aiqiang Dong |
| author_facet | Ning Gao Xuebiao Li Minjian Kong Ming Ni Dongdong Wei Xian Zhu Yifan Wang Ze Hong Aiqiang Dong |
| author_sort | Ning Gao |
| collection | DOAJ |
| description | BackgroundAlthough studies suggest that concentrations of serum 25-hydroxyvitamin D (25(OH)D) are lower in individuals with Heart Failure (HF), the beneficial effects of vitamin D supplementation are controversial. Therefore, in this study, we aimed to determine whether there is a causal relationship between serum Vitamin D (VD) levels and HF.MethodsWe obtained genetic instruments from the largest available genome-wide association study (GWAS) of European descent for 25(OH)D (443, 734 individuals) to investigate the association with HF (47,309 cases, 930,014 controls), and vice versa. Two-sample bidirectional Mendelian Randomization (MR) analysis was performed to infer the causality. In addition to the primary analysis using inverse variance-weighted (IVW) MR, we applied five additional methods to control for pleiotropy [MR-Egger, weighted median, Maximum-likelihood, MR-robust adjusted profile score (MR-RAPS) and MR-pleiotropy residual sum and outlier (MR-PRESSO)] and compared their respective MR estimates. We also performed a sensitivity analysis to ensure that our results were robust.ResultsMendelian randomized analysis showed that increased serum 25(OH)D was associated with a lower risk of HF in the IVW method (odds ratio [OR] = 0. 81;95%CI, 0.70–0.94, P = 0.006). In the reverse MR analyses, the genetic predisposition to HF was negatively correlated with serum 25(OH)D level (OR = 0. 89;95%CI, (0.82–0.97), P = 0.009).ConclusionOur study revealed the possible causal role of 25(OH)D on decreasing the risk for HF. Meanwhile, reverse MR analysis suggested that HF may be associated with lower vitamin D levels, it could be the potential implications for dietary recommendations. |
| first_indexed | 2024-04-12T15:28:14Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T15:28:14Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-99e0edce400b42ea9375552e1cd6f8662022-12-22T03:27:12ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.910949910949Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization StudyNing GaoXuebiao LiMinjian KongMing NiDongdong WeiXian ZhuYifan WangZe HongAiqiang DongBackgroundAlthough studies suggest that concentrations of serum 25-hydroxyvitamin D (25(OH)D) are lower in individuals with Heart Failure (HF), the beneficial effects of vitamin D supplementation are controversial. Therefore, in this study, we aimed to determine whether there is a causal relationship between serum Vitamin D (VD) levels and HF.MethodsWe obtained genetic instruments from the largest available genome-wide association study (GWAS) of European descent for 25(OH)D (443, 734 individuals) to investigate the association with HF (47,309 cases, 930,014 controls), and vice versa. Two-sample bidirectional Mendelian Randomization (MR) analysis was performed to infer the causality. In addition to the primary analysis using inverse variance-weighted (IVW) MR, we applied five additional methods to control for pleiotropy [MR-Egger, weighted median, Maximum-likelihood, MR-robust adjusted profile score (MR-RAPS) and MR-pleiotropy residual sum and outlier (MR-PRESSO)] and compared their respective MR estimates. We also performed a sensitivity analysis to ensure that our results were robust.ResultsMendelian randomized analysis showed that increased serum 25(OH)D was associated with a lower risk of HF in the IVW method (odds ratio [OR] = 0. 81;95%CI, 0.70–0.94, P = 0.006). In the reverse MR analyses, the genetic predisposition to HF was negatively correlated with serum 25(OH)D level (OR = 0. 89;95%CI, (0.82–0.97), P = 0.009).ConclusionOur study revealed the possible causal role of 25(OH)D on decreasing the risk for HF. Meanwhile, reverse MR analysis suggested that HF may be associated with lower vitamin D levels, it could be the potential implications for dietary recommendations.https://www.frontiersin.org/articles/10.3389/fnut.2022.910949/fullvitamin Dheart failureMendelian randomizationthe causal linkgenome-wide association study |
| spellingShingle | Ning Gao Xuebiao Li Minjian Kong Ming Ni Dongdong Wei Xian Zhu Yifan Wang Ze Hong Aiqiang Dong Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study Frontiers in Nutrition vitamin D heart failure Mendelian randomization the causal link genome-wide association study |
| title | Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study |
| title_full | Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study |
| title_fullStr | Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study |
| title_full_unstemmed | Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study |
| title_short | Associations Between Vitamin D Levels and Risk of Heart Failure: A Bidirectional Mendelian Randomization Study |
| title_sort | associations between vitamin d levels and risk of heart failure a bidirectional mendelian randomization study |
| topic | vitamin D heart failure Mendelian randomization the causal link genome-wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.910949/full |
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