Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model
Gene expression has inherent stochasticity resulting from transcription's burst manners. Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics, using mathematical models as blueprints. The classical telegraph model (CTM) has been widely used to explain tr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2023-04-01
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| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.221057 |