Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model
Gene expression has inherent stochasticity resulting from transcription's burst manners. Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics, using mathematical models as blueprints. The classical telegraph model (CTM) has been widely used to explain tr...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Royal Society
2023-04-01
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Series: | Royal Society Open Science |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.221057 |