Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model
Gene expression has inherent stochasticity resulting from transcription's burst manners. Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics, using mathematical models as blueprints. The classical telegraph model (CTM) has been widely used to explain tr...
Main Authors: | Songhao Luo, Zhenquan Zhang, Zihao Wang, Xiyan Yang, Xiaoxuan Chen, Tianshou Zhou, Jiajun Zhang |
---|---|
Format: | Article |
Language: | English |
Published: |
The Royal Society
2023-04-01
|
Series: | Royal Society Open Science |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.221057 |
Similar Items
-
Synergising single-cell resolution and 4sU labelling boosts inference of transcriptional bursting
by: David M. Edwards, et al.
Published: (2023-06-01) -
Variability of the innate immune response is globally constrained by transcriptional bursting
by: Nissrin Alachkar, et al.
Published: (2023-06-01) -
From Snapshot to Snapchat
by: Jørgen Riber Christensen, et al.
Published: (2015-10-01) -
Signaling Mechanism of Transcriptional Bursting: A Technical Resolution-Independent Study
by: Yaolai Wang, et al.
Published: (2020-10-01) -
SNAPSHOTS. Images, crowds, thoughts. A conversation with Susan Buck-Morss
by: Aurora Fernández Polanco
Published: (2014-12-01)