Microenvironmental changes co-occur with mosaic somatic clonal expansions in normal skin and esophagus tissues

The presence of somatic mutations, previously identified in cancers, are being increasingly recognized in normal tissues. While the role of microenvironment (ME) in tumor progression is well understood, the changes that occur in the microenvironment of normal tissues that harbor somatic mutations ha...

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Bibliographic Details
Main Authors: C. Munugula, J. Hu, E. Christodoulou, V. Yellapantula
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1021940/full