A truncated AdeS kinase protein generated by ISAba1 insertion correlates with tigecycline resistance in Acinetobacter baumannii.

A truncated AdeS kinase protein generated by ISAba1 insertion correlates with tigecycline resistance in Acinetobacter baumannii.

Over-expression of AdeABC efflux pump stimulated continuously by the mutated AdeRS two component system has been found to result in antimicrobial resistance, even tigecycline (TGC) resistance, in multidrug-resistant Acinetobacter baumannii (MRAB). Although the insertion sequence, ISAba1, contributes...

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Bibliographic Details
Main Authors: Jun-Ren Sun, Cherng-Lih Perng, Ming-Chin Chan, Yuji Morita, Jung-Chung Lin, Chih-Mao Su, Wei-Yao Wang, Tein-Yao Chang, Tzong-Shi Chiueh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3498117?pdf=render

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http://europepmc.org/articles/PMC3498117?pdf=render

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