The Smoothened agonist SAG Modulates the Male and Female Peripheral Immune Systems Differently in an Immune Model of Central Nervous System Demyelination

The Smoothened agonist SAG Modulates the Male and Female Peripheral Immune Systems Differently in an Immune Model of Central Nervous System Demyelination

Both Hedgehog and androgen signaling pathways are known to promote myelin regeneration in the central nervous system. Remarkably, the combined administration of agonists of each pathway revealed their functional cooperation towards higher regeneration in demyelination models in males. Since multiple...

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Bibliographic Details
Main Authors: Abdelmoumen Kassoussi, Amina Zahaf, Tom Hutteau-Hamel, Claudia Mattern, Michael Schumacher, Pierre Bobé, Elisabeth Traiffort
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Cells
Subjects:
oligodendrocyte
microglia
myelination
Hedgehog signaling
androgen
cytokine
Online Access:https://www.mdpi.com/2073-4409/13/8/676

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https://www.mdpi.com/2073-4409/13/8/676

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