In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

In Silico Investigation of Parkin-Activating Mutations Using Simulations and Network Modeling

Complete loss-of-function mutations in the PRKN gene are a major cause of early-onset Parkinson’s disease (PD). PRKN encodes the Parkin protein, an E3 ubiquitin ligase that works in conjunction with the ubiquitin kinase PINK1 in a distinct quality control pathway to tag damaged mitochondria for auto...

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Bibliographic Details
Main Authors: Naeyma N. Islam, Caleb A. Weber, Matt Coban, Liam T. Cocker, Fabienne C. Fiesel, Wolfdieter Springer, Thomas R. Caulfield
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomolecules
Subjects:
Parkinson’s disease
parkin
network modeling
molecular dynamics simulation
Online Access:https://www.mdpi.com/2218-273X/14/3/365

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https://www.mdpi.com/2218-273X/14/3/365

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