Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways

Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways

Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear. Via generating Vam6+/- mice and using flow cytometry, image approach, and RNA sequencing, we studied the role of Vam6 in controllin...

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Bibliographic Details
Main Authors: Shiyu Bai, Qielan Wu, Shasha Zhu, Yuwei Zhang, Xuran Chen, Miya Su, Jun Pan, Shuhang Li, Ting Yue, Linfeng Xu, Di Xie, Chenxi Tian, Dan Zhao, Xiang Li, Junjie Hou, Lu Wang, Sicheng Fu, Yanhong Xue, Amin Jiang, Dong Li, Tao Xu, Zhigang Tian, Rongbin Zhou, Huimin Zhang, Li Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
Vam6
mTORC1
AMPK
Rab7a-Vam6-AMPK complex
iNKT cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051045/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1051045/full

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