HYpofractionated, dose-redistributed RAdiotherapy with protons and photons to combat radiation-induced immunosuppression in head and neck squamous cell carcinoma: study protocol of the phase I HYDRA trial

HYpofractionated, dose-redistributed RAdiotherapy with protons and photons to combat radiation-induced immunosuppression in head and neck squamous cell carcinoma: study protocol of the phase I HYDRA trial

Abstract Background Radiotherapy (RT) is the standard of care for most advanced head and neck squamous cell carcinoma (HNSCC) and results in an unfavorable 5-year overall survival of 40%. Despite strong biological rationale, combining RT with immune checkpoint inhibitors does not result in a surviva...

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Bibliographic Details
Main Authors: Joris B. W. Elbers, Pascal A. Gunsch, Reno Debets, Stijn Keereweer, Esther van Meerten, Jaap Zindler, Yvette van Norden, Mischa S. Hoogeman, Gerda M. Verduijn, Michiel Kroesen, Remi A. Nout
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Cancer
Subjects:
Hypofractionation
Radiotherapy
HNSCC
Proton therapy
Immune system
Immunotherapy
Online Access:https://doi.org/10.1186/s12885-023-11031-w

Internet

https://doi.org/10.1186/s12885-023-11031-w

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