Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus

Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus

Abstract Objective Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal activation of the type I interferon (IFN) pathway, which results in tissue inflammation and organ damage. We explored the role of the RhoA GTPase in the type I IFN activation pathway to provide...

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Bibliographic Details
Main Authors: Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng, Richard Bucala
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Arthritis Research & Therapy
Subjects:
Autoimmunity
Systemic lupus erythematosus
RhoA
Type I IFN
RhoA/ROCK inhibitor
Online Access:https://doi.org/10.1186/s13075-024-03263-3

Internet

https://doi.org/10.1186/s13075-024-03263-3

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