New pan-ALK inhibitor-resistant EML4::ALK mutations detected by liquid biopsy in lung cancer patients

New pan-ALK inhibitor-resistant EML4::ALK mutations detected by liquid biopsy in lung cancer patients

Abstract ALK and ROS1 fusions are effectively targeted by tyrosine kinase inhibitors (TKIs), however patients inevitably relapse after an initial response, often due to kinase domain mutations. We investigated circulating DNA from TKI-relapsed NSCLC patients by deep-sequencing. New EML4::ALK substit...

Full description

Bibliographic Details
Main Authors: Matteo Villa, Federica Malighetti, Elisa Sala, Geeta G. Sharma, Giulia Arosio, Maria Gemelli, Chiara Manfroni, Diletta Fontana, Nicoletta Cordani, Raffaella Meneveri, Alfonso Zambon, Rocco Piazza, Fabio Pagni, Diego Cortinovis, Luca Mologni
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-024-00498-w

Internet

https://doi.org/10.1038/s41698-024-00498-w

Similar Items